3dRNA Web Server

Automatic building of ncRNA 3D structures

3dRNA is an automatic, fast, and high-accuracy RNA tertiary structure prediction method. It uses sequence and secondary structure information to build three dimensional structures of RNA from template segments.

The main routines for 3dRNA is:
  1. Break the given secondary structure into segments;
  2. Find the template of these segments from library, which is built from crystal or NMR structures. If the template is missing, a distance-geometry-based loop building method can be used to build the segment ab initio.
  3. A random template for each segment will be selected to construct the final RNA 3D structure.
  4. Moreover, 3dRNA is able to optimize a given structure by Simulated Annealing Monte Carlo method, and this process can further improve the prediction.

Validation data for Circular RNA and DNA

The data used in our paper is listed below, you can download them and validate them in our web server.

Circular RNA